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Enzyme-free triboelectric biosensor with glucose response molecularly imprinted polymer for self-powered biomedical monitoring
葡萄糖響應分子印跡聚合物的無酶摩擦電生物感測器,用於自供能生物醫學監測


Y.H. Chang, L.Y. Chang, C.C. Chang, Y.S. Chiu, P. Kanokpaka, K.C. Ho*, H. Mizuguchi, M.H. Yeh*
Nano Energy, 2024,
https://doi.org/10.1016/j.nanoen.2023.109114
SEED Member: W.S. Hung, M.H. Yeh

 
 

Major Contributions

1. Development of an Innovative Enzyme-Free, Self-Powered Glucose Sensor
We designed a glucose-responsive molecularly imprinted polymer-based triboelectric sensor (GRMIP-TES) that operates without enzymes or external power sources. By leveraging triboelectric technology, the sensor converts mechanical energy into electrical energy, enabling stable and selective glucose detection. This approach addresses the limitations of enzymatic sensors, such as instability under environmental factors, while offering high sensitivity and reliability.

2. Integration of Molecularly Imprinted Polymers with Triboelectric Technology
We successfully combined molecularly imprinted polymers (MIPs) with triboelectric sensing technology to create a dual-functional system. The MIP layer on carbon cloth provides selective glucose recognition through reversible adsorption and extraction, while also enhancing the triboelectric output. This integration demonstrates the feasibility of using MIPs in self-powered biosensors.

3. Creation of a Non-Invasive, Real-Time Glucose Monitoring Platform
The GRMIP-TES can accurately detect glucose concentrations in the range of 0–20 mM and provide real-time alerts by lighting LEDs. It shows excellent anti-interference performance against other blood components (e.g., ascorbic acid, uric acid) and maintains high reusability. This platform offers a practical, non-invasive solution for diabetes management.


主要貢獻

1. 創新設計無酶自供能葡萄糖感測器
我們開發了一種基於葡萄糖響應分子印跡聚合物的無酶摩擦電感測器(GRMIP-TES),可在無需酶或外部電源的情況下運行。該感測器利用摩擦電技術,將機械能轉換為電能,實現穩定且選擇性的葡萄糖檢測。此方法克服了酶基感測器在環境因素下不穩定的缺點,同時提供了高靈敏度和可靠性。

2. 成功整合分子印跡聚合物與摩擦電技術
我們成功將分子印跡聚合物(MIP)與摩擦電感測技術結合,創建了一個雙功能系統。碳布上的MIP層通過可逆吸附和萃取實現對葡萄糖的選擇性識別,同時增強了摩擦電輸出。這一整合展示了在自供能生物感測器中使用MIP的可行性。

3. 實現即時、非侵入式的葡萄糖監控平台
GRMIP-TES可準確檢測0–20 mM範圍內的葡萄糖濃度,並通過點亮LED燈提供即時警示。該系統對其他血液成分(如抗壞血酸、尿酸等)具有出色的抗干擾性能,且具備高重複使用性。此平台為糖尿病管理提供了一種實用且非侵入式的解決方案。